Low Concentration H2O2/TiO_N in Office Bleaching

• Published in: Journal of dental research Vol. 93; no. 7_suppl; pp. 66S - 71S
• Main Authors: Bortolatto, J F, Pretel, H, Floros, M C, Luizzi, ACC, Dantas, AAR, Fernandez, E, Moncada, G, Oliveira, OB de
• Format: Journal Article
• Language: English
• Published: Alexandria SAGE PUBLICATIONS, INC 01.07.2014
• Subjects: Bleaching; Clinical trials; Free radicals; Hydrogen peroxide; Lasers; Light; Nanoparticles; Patient safety; Spectroscopy; Teeth; Brazil
• ISSN: 0022-0345; 1544-0591
• DOI: 10.1177/0022034514537466

Objectives: The purpose of this randomized double-blinded clinical trial was to test the efficacy and tooth sensitivity promoted by the use of an in-office 15% H2O2 bleaching agent containing nanoparticles of TiO_N photocatalyzed with LED/laser light (HP15) and a control of 35% H2O2 (HP35). Methods: Forty healthy volunteers, both sexes, aged 18 to 25 yr, were randomly distributed in 2 groups: HP15 (n = 20) was treated in 3 sessions of 48 min each, and HP35 (n = 20) was treated in 3 sessions of 45 min each. The efficacy (E) was evaluated by ΔE values measured via reflectance spectroscopy. The tooth sensitivity (S) was analyzed by visual analog scale (low, average, high, very high). The absolute risk reduction and the number needed to treat index were calculated. The data were analyzed by mixed repeated measures analysis of variance with Bonferroni-correction t test (α = 0.05). Results: For the efficacy, significant differences were found for number of bleaching sessions (p = .0001; ηp2 = 0.73 and π = 1.000) and for the interaction of number of sessions and bleaching protocols (p = .0001; ηp2 = 0.319 and π = 1.000. The tooth sensitivity level showed significant differences only between the bleaching protocols. Absolute risk reduction calculated was 52% and number needed to treat, 1.92. Conclusions: The bleaching agent with the lower concentration (HP15) promoted lower levels of tooth sensitivity and presented greater efficacy compared to the control (HP35) in patients between 18 and 25 yr old. The limitation of short-term evaluation did not provide information about the longevity of the tooth bleaching (Brazilian Clinical Trials Registry Re Bec no. U1111-1150-4466).