A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents

An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wi...

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Published inChemical communications (Cambridge, England) Vol. 53; no. 80; pp. 11008 - 11011
Main Authors Sloan, Nikki L, Luthra, Sajinder K, McRobbie, Graeme, Pimlott, Sally L, Sutherland, Andrew
Format Journal Article
LanguageEnglish
Published 05.10.2017
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Summary:An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described. The mild conditions are tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of 125I-labelled aryl compounds and SPECT radiotracers.
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ISSN:1364-548X
DOI:10.1039/c7cc06211g