Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre

Of these hemoglobinopathies, thalassemia syndrome, particularly ß-thalassemia major is a serious and common cause of morbidity. [...]social stigma associated with having thalassemia havesignificant psychosocial, financial and emotional impact onpatients and their families. According to WHO, 5% of th...

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Published inDicle tıp dergisi Vol. 46; no. 2; pp. 269 - 276
Main Authors Jain, Promil, Gupta, Monika, Dua, Shivani, Marwah, Nisha, Gill, Meenu, Sen, Rajeev
Format Journal Article
LanguageEnglish
Published Diyarbakir Dicle University 01.06.2019
Subjects
Blood transfusions
Chromatography
Hematology
Hemoglobin
Laboratories
Population
Public health
Retention
West Bengal
India
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Summary:Of these hemoglobinopathies, thalassemia syndrome, particularly ß-thalassemia major is a serious and common cause of morbidity. [...]social stigma associated with having thalassemia havesignificant psychosocial, financial and emotional impact onpatients and their families. According to WHO, 5% of the world population is carrier for hemoglobin disorders3. [...]the study was planned to find out the prevalence of various hemoglobinopathies in state of Haryana and to assess the role of HPLC for an accurate and quick diagnosis of various hemoglobin disorders. Few patients had borderline results as their chromatogram showed value of HbA2 between 3.5-3.9%.Most of them were antenatal mothers and were advised to get repeat HPLC screening done after correction of anemia as HbA2 levels are spuriously high in megaloblasticanemia. [...]screening of husband for HPLC was also advised. ß-thalassemia homozygous was found in 43 cases, out of which 19 patients were diagnosed as ß-thalassemia major, 24 were diagnosed as ß-thalassemia intermedia.
ISSN:1300-2945
1308-9889
DOI:10.5798/dicletip.539869