Evaluation of genotoxicity after application of Listerine registered on human lymphocytes by micronucleus and single cell gel electrophoresis assays

Listerine (LN) is one of the most commonly used mouth rinses worldwide although very limited information is available concerning its genotoxicity. In another view, the biological safety profile of oral care products is frequently assumed on the basis of simplistic test models. Therefore, the present...

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Bibliographic Details
Published inToxicology and industrial health Vol. 28; no. 3; pp. 271 - 275
Main Authors Tuerkez, Hasan, Toar, Basak, Arabaci, Taner
Format Journal Article
LanguageEnglish
Published 01.04.2012
Subjects
Blood
Culture
Electrophoresis
Genetics
Genotoxicity
Human
Lymphocytes
Toxicology
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Summary:Listerine (LN) is one of the most commonly used mouth rinses worldwide although very limited information is available concerning its genotoxicity. In another view, the biological safety profile of oral care products is frequently assumed on the basis of simplistic test models. Therefore, the present study was undertaken to investigate the in vitro genotoxic potential of LN using micronucleus and single cell gel electrophoresis tests as genetic endpoints. Different concentrations of LN (0-100% of ml/culture, v/v) were applied to whole human blood cultures (n = 5). The result of the present study showed that there were no statistically significant differences (p > 0.05) between the control group and the groups treated with LN alone in both analysed endpoints. In conclusion, our result first demonstrated the absence of genotoxicity of LN on human lymphocytes.
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ISSN:0748-2337
DOI:10.1177/0748233711410918