Expeditious synthesis of the tetrasaccharide cap domain of the Leishmania donovanilipophosphoglycan using one-pot glycosylation reactions

Expeditious syntheses of the tetrasaccharide cap related to the lipophosphoglycan of Leishmania donovanifrom two monosaccharides and a disaccharide building block were achieved by one-pot sequential glycosylation reactions. The monosaccharide building blocks were synthesized from d-mannose, and the...

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Bibliographic Details
Published inRSC advances Vol. 6; no. 51; pp. 45112 - 45119
Main Authors Mukherjee, Mana Mohan, Basu, Nabamita, Ghosh, Rina
Format Journal Article
LanguageEnglish
Published 01.05.2016
Subjects
Glucose
Lactose
Leishmania
Monosaccharides
Oxidation-Reduction
Synthesis (chemistry)
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Summary:Expeditious syntheses of the tetrasaccharide cap related to the lipophosphoglycan of Leishmania donovanifrom two monosaccharides and a disaccharide building block were achieved by one-pot sequential glycosylation reactions. The monosaccharide building blocks were synthesized from d-mannose, and the disaccharide building block was prepared from lactose by C2-epimerisation of its glucose unit through C2 hydroxy oxidation-reduction.
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SourceType-Scholarly Journals-1
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ISSN:2046-2069
DOI:10.1039/c6ra03856e