Cys-tRNA super(Cys) formation and cysteine biosynthesis in methanogenic archaea: two faces of the same problem?

Aminoacyl-tRNA (transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNA super(Cys) formation in three methanogenic archaea (Me...

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Published inCellular and molecular life sciences : CMLS Vol. 61; no. 19-20; pp. 2437 - 2445
Main Authors Ambrogelly, A, Kamtekar, S, Sauerwald, A, Ruan, B, Tumbula-Hansen, D, Kennedy, D, Ahel, I, Soell, D
Format Journal Article
LanguageEnglish
Published 01.10.2004
Subjects
Archaea
Methanocaldococcus jannaschii
Methanopyrus kandleri
Methanothermobacter thermautotrophicus
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Summary:Aminoacyl-tRNA (transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNA super(Cys) formation in three methanogenic archaea (Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri) is still unknown, since no recognizable gene for a canonical cysteinyl-tRNA synthetase could be identified in the genome sequences of these organisms. Here we review the different routes recently proposed for Cys-tRNA super(Cys) formation and discuss its possible link with cysteine biosynthesis in these methanogenic archaea.
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ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-004-4194-9