EFFECTS OF COEXPOSURE OF HEAVY METALS AND DRUGS ON CENTRAL NERVOUS SYSTEM: PART II

• Published in: Polymers research journal Vol. 10; no. 1; p. 7
• Main Authors: Karpukhina, O V, Gumargalieva, K Z, Inozemtsev, A N, Vahedi, S M
• Format: Journal Article
• Language: English
• Published: Hauppauge Nova Science Publishers, Inc 01.01.2016
• Subjects: Antioxidants; Aqueous solutions; Cadmium; Central nervous system; Cigarettes; Cognitive enhancement; Combinatorial analysis; Dangerous; Drugs; Enzymes; Free radicals; Heavy metals; Lipid peroxidation; Lipids; Memory; Metals; Neurotoxicity; Polymers; Reagents; Spectrum analysis; Vitamin C
• ISSN: 1935-2530

As indicated in Part I, most of the publications aimed to analyze combinatorial effects on the human CNS are focused on chemical agents present in water, air, cigarette smoke, etc., where in addition to heavy metals, there are other particles. This makes it impossible to analyze results of joint influence of the heavy metals and compare it with the effects of each of them individually. There are few works on animals that could solve this problem. However, they found that different heavy metals together cause greater adverse impacts than each of them alone. Few works on the joint effects of heavy metals and drugs established that combinations of metals with piracetam and hidazepam can cause a greater neurotoxic effect than each metal alone, which makes it dangerous to use such preparations in the regions with a high environmental content of heavy metals. The conclusion is done about the relevance of the search for medicines to counteract the neurotoxic effects of heavy metals, especially in view of the increasing adverse impact caused by their mixtures.