Effects of renal sympathetic nerve radiofrequency ablation on norepinephrine spillover rate and sympathetic nerve activity in dogs with hypertension

• Published in: Jie fang jun yi xue za zhi Vol. 37; no. 11; pp. 880 - 883
• Main Authors: YU, Hang, Cheng-ming, YANG, Hui-jie, LI, Chun-yu, ZENG, Yu-qiang, FANG, HE, Duo-fen, ZHANG, Xiao-qun, Chun-lan, WEN
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.11.2012
• Subjects: Blood pressure; Circulatory system; Coronary vessels; Hypertension; Reflexes
• ISSN: 0577-7402

Objective 　To evaluate the validity and explore the mechanism of renal sympathetic denervation (RSD) in the treatment of dogs with hypertension reproduced by constriction of abdominal aorta. Methods 　The hypertension model was reproduced by constriction of abdominal aorta in 20 adult healthy dogs. These dogs were then randomly divided into the treatment group and control group (10 each). Renal sympathetic nerve radiofrequency ablation was done in treatment group 1 month after modeling. The foreleg blood pressure, sympathetic activity and norepinephrine overflow rate of dogs in two groups were detected before modeling, and 1, 2 and 3 months after modeling, and the trend of the change was also observed. Results 　One month after modeling, the systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) were elevated significantly in control group (146.7±21.0, 89.0±12.7 and 108.3±14.9mmHg) compared with those before modeling (119.5±13.2, 76.5±7.8 and 90.9±8mmHg, P < 0.05).