Copper/Palladium-Catalyzed 1,4 Reduction and Asymmetric Allylic Alkylation of [alpha],[beta]-Unsaturated Ketones: Enantioselective Dual Catalysis

Cooperative efforts: The catalytic coupling of the two organometallic intermediates is possible through a Cu/Pd-based dual catalysis (see scheme; LG=leaving group), in which the Cu catalytic cycle generates catalytically the starting material for the Pd catalytic cycle. Although reagents are present...

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Published inAngewandte Chemie International Edition Vol. 52; no. 11; pp. 3208 - 3212
Main Authors Nahra, Fady, Macé, Yohan, Lambin, Dominique, Riant, Olivier
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 11.03.2013
EditionInternational ed. in English
Subjects
Alkylation
Asymmetry
Catalysis
Catalysts
Copper
Joining
Ketones
Metalorganic compounds
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Summary:Cooperative efforts: The catalytic coupling of the two organometallic intermediates is possible through a Cu/Pd-based dual catalysis (see scheme; LG=leaving group), in which the Cu catalytic cycle generates catalytically the starting material for the Pd catalytic cycle. Although reagents are present in stoichiometric amounts in the reaction mixture and are able to trap both active species, the desired reaction proceeds as planned.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201208612