A Facile One-Pot Transformation of Baylis-Hillman Adducts into Unsymmetrical Disubstituted Maleimide and Maleic Anhydride Frameworks: A Facile Synthesis of HimanimideA

Unsymmetrical, disubstituted maleimide and maleic anhydride frameworks have been accessed from Baylis-Hillman adducts in an operationally simple three-step (Friedel-Crafts reaction, selective hydrolysis, and cyclization), one-pot strategy. This strategy has been successfully extended to the synthesi...

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Bibliographic Details
Published inChemistry : a European journal Vol. 16; no. 7; pp. 2031 - 2035
Main Authors Basavaiah, Deevi, Devendar, Badugu, Aravindu, Kunche, Veerendhar, Ainelly
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 15.02.2010
Subjects
Adducts
Biocompatibility
Chemistry
Friedel-Crafts reaction
Hydrolysis
Maleic anhydride
Strategy
Synthesis
Transformations
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Summary:Unsymmetrical, disubstituted maleimide and maleic anhydride frameworks have been accessed from Baylis-Hillman adducts in an operationally simple three-step (Friedel-Crafts reaction, selective hydrolysis, and cyclization), one-pot strategy. This strategy has been successfully extended to the synthesis of a representative bioactive compound, himanimideA (see scheme).
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ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200902887