自身免疫性胰腺炎及其合并IgG4相关硬化性胆管炎的临床特征和预后比较

目的 比较分析单纯自身免疫性胰腺炎(AIP)与AIP合并IgG4相关硬化性胆管炎(IgG4-SC)患者的临床特征差异、诊治和预后。 方法 回顾性分析2015年6月—2020年1月郑州大学第一附属医院收治的40例1型AIP患者资料，其中包括29例单纯AIP患者及11例AIP合并IgG4-SC患者，对比两组患者的临床表现、实验室检查、影像学表现、治疗及预后。正态分布的计量资料两组间比较采用t检验，非正态分布的计量资料两组间比较采用Mann-Whitney U检验。计数资料两组间比较采用Fisher确切检验。采用Kaplan-Meier法计算患者复发率并绘制复发曲线，采用log-rank检验进行比较...

Full description

Saved in:
Bibliographic Details
Published inLinchuang gandanbing zazhi Vol. 37; no. 4; pp. 888 - 892
Main Authors 丁航, 郑琳琳, 刘源, 张连峰, 周琳
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.01.2021
郑州大学第一附属医院消化内科,郑州450052
Subjects
Cholangitis
Pancreatitis
预后
胆管炎
诊断
自身免疫性胰腺炎
治疗学
Online AccessGet full text
ISSN1001-5256
2097-3497
DOI10.3969/j.issn.1001-5256.2021.04.032

Cover

Abstract 目的 比较分析单纯自身免疫性胰腺炎(AIP)与AIP合并IgG4相关硬化性胆管炎(IgG4-SC)患者的临床特征差异、诊治和预后。 方法 回顾性分析2015年6月—2020年1月郑州大学第一附属医院收治的40例1型AIP患者资料，其中包括29例单纯AIP患者及11例AIP合并IgG4-SC患者，对比两组患者的临床表现、实验室检查、影像学表现、治疗及预后。正态分布的计量资料两组间比较采用t检验，非正态分布的计量资料两组间比较采用Mann-Whitney U检验。计数资料两组间比较采用Fisher确切检验。采用Kaplan-Meier法计算患者复发率并绘制复发曲线，采用log-rank检验进行比较。 结果 与单纯AIP组相比，AIP合并IgG4-SC组受累器官数目更多[3.0(3.0~4.0)个vs 3.0(1.5~3.5)个，Z=-2.172，P=0.035]，治疗前反应指数更高[12.0(12.0~15.0) vs 12.0(9.0~13.5)，Z=-2.157，P=0.032]。AIP合并IgG4-SC组血清IgG水平为21.0(15.8~23.7)g/L，高于单纯AIP组的14.8(13.3~15.7)g/L，差异有统计学意义(Z=-2.711，P=0.004)。在中位随访时间15.8(6.5~31.3)个月内，AIP合并IgG4-SC组复发率明显高于单纯AIP组，差异有统计学意义(χ2=8.155，P=0.004)。 结论 AIP合并IgG4-SC组血清IgG4水平更高、受累器官更多，且更易出现复发。早期识别、诊断和治疗可降低AIP的复发率。
AbstractList R576%R575.7; 目的 比较分析单纯自身免疫性胰腺炎(AIP)与AIP合并IgG4相关硬化性胆管炎(IgG4-SC)患者的临床特征差异、诊治和预后.方法 回顾性分析2015年6月—2020年1月郑州大学第一附属医院收治的40例1型AIP患者资料,其中包括29例单纯AIP患者及11例AIP合并IgG4-SC患者,对比两组患者的临床表现、实验室检查、影像学表现、治疗及预后.正态分布的计量资料两组间比较采用t检验,非正态分布的计量资料两组间比较采用Mann-Whitney U检验.计数资料两组间比较采用Fisher确切检验.采用Kaplan-Meier法计算患者复发率并绘制复发曲线,采用log-rank检验进行比较.结果 与单纯AIP组相比,AIP合并IgG4-SC组受累器官数目更多[3.0(3.0～4.0)个vs 3.0(1.5～3.5)个,Z=-2.172,P=0.035],治疗前反应指数更高[12.0(12.0～15.0)vs 12.0(9.0～13.5),Z=-2.157,P=0.032].AIP合并IgG4-SC组血清IgG水平为21.0(15.8～23.7)g/L,高于单纯AIP组的14.8(13.3～15.7)g/L,差异有统计学意义(Z=-2.711,P=0.004).在中位随访时间15.8(6.5～31.3)个月内,AIP合并IgG4-SC组复发率明显高于单纯AIP组,差异有统计学意义(χ2=8.155,P=0.004).结论 AIP合并IgG4-SC组血清IgG4水平更高、受累器官更多,且更易出现复发.早期识别、诊断和治疗可降低AIP的复发率.
目的 比较分析单纯自身免疫性胰腺炎(AIP)与AIP合并IgG4相关硬化性胆管炎(IgG4-SC)患者的临床特征差异、诊治和预后。 方法 回顾性分析2015年6月—2020年1月郑州大学第一附属医院收治的40例1型AIP患者资料，其中包括29例单纯AIP患者及11例AIP合并IgG4-SC患者，对比两组患者的临床表现、实验室检查、影像学表现、治疗及预后。正态分布的计量资料两组间比较采用t检验，非正态分布的计量资料两组间比较采用Mann-Whitney U检验。计数资料两组间比较采用Fisher确切检验。采用Kaplan-Meier法计算患者复发率并绘制复发曲线，采用log-rank检验进行比较。 结果 与单纯AIP组相比，AIP合并IgG4-SC组受累器官数目更多[3.0(3.0~4.0)个vs 3.0(1.5~3.5)个，Z=-2.172，P=0.035]，治疗前反应指数更高[12.0(12.0~15.0) vs 12.0(9.0~13.5)，Z=-2.157，P=0.032]。AIP合并IgG4-SC组血清IgG水平为21.0(15.8~23.7)g/L，高于单纯AIP组的14.8(13.3~15.7)g/L，差异有统计学意义(Z=-2.711，P=0.004)。在中位随访时间15.8(6.5~31.3)个月内，AIP合并IgG4-SC组复发率明显高于单纯AIP组，差异有统计学意义(χ2=8.155，P=0.004)。 结论 AIP合并IgG4-SC组血清IgG4水平更高、受累器官更多，且更易出现复发。早期识别、诊断和治疗可降低AIP的复发率。
Author 丁航
周琳
刘源
张连峰
郑琳琳
AuthorAffiliation 郑州大学第一附属医院消化内科,郑州450052
AuthorAffiliation_xml – name: 郑州大学第一附属医院消化内科,郑州450052
Author_FL LIU Yuan
DING Hang
ZHENG Linlin
ZHANG Lianfeng
ZHOU Lin
Author_FL_xml – sequence: 1
  fullname: DING Hang
– sequence: 2
  fullname: ZHENG Linlin
– sequence: 3
  fullname: LIU Yuan
– sequence: 4
  fullname: ZHANG Lianfeng
– sequence: 5
  fullname: ZHOU Lin
Author_xml – sequence: 1
  fullname: 丁航
– sequence: 2
  fullname: 郑琳琳
– sequence: 3
  fullname: 刘源
– sequence: 4
  fullname: 张连峰
– sequence: 5
  fullname: 周琳
BookMark eNpF0E9LAkEABfAhDDLzU9Shy26zOzuzO8eQMkHo4jmZ2T-iyGpuEniqdPsjZhLhoU52CTIqKEQ9-Gkad_sWWUad3uXHe_CWQcQtuTYAawqUESV0oyDnPc-VFQgVCauYyCpUFRlqMkTqAoiqkOoS0qgeAdE_swTinpfnECuIUA2TKNgLzx7DcV_4l0G3Pz16COuvoT8OTtriqin8geici9EglUtqwd1Q-G9B70m0uj_uNHjuzVxw2_gYvotxM7gYicmxuG593jdEpz19uQkn9RWw6LCiZ8d_MwYy21uZxI6U3k2mEptpqUwULHGdY-RopmMyotvcsLFpIowsTLhhUA4tSrHl6FThNjMsiJjBuE4UygyqIW5ZKAbW57WHzHWYm8sWStWKOxvMFs2cxWu172-gBmelMbA6p-VKab9qewf_FqmI6rpGkIG-AFF-h9k
ClassificationCodes R576%R575.7
ContentType Journal Article
Copyright 2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: 2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 3V.
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
2B.
4A8
92I
93N
PSX
TCJ
DOI 10.3969/j.issn.1001-5256.2021.04.032
DatabaseName ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni)
Medical Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitle Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
DatabaseTitleList
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitle_FL Clinical features and prognosis of autoimmune pancreatitis alone or with IgG4-related sclerosing cholangitis
EISSN 2097-3497
EndPage 892
ExternalDocumentID lcgdbzz202104035
GroupedDBID -05
3V.
5XA
5XF
7X7
7XB
88E
8FI
8FJ
8FK
92F
92I
ABDBF
ABJNI
ABUWG
ACGFS
ACUHS
AFKRA
ALMA_UNASSIGNED_HOLDINGS
AZQEC
BENPR
CCEZO
CCPQU
CIEJG
CW9
DWQXO
EAD
EAP
EOJEC
ESX
FYUFA
K9.
M1P
OBODZ
OK1
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
RNS
TCJ
TGQ
U1G
U5O
2B.
4A8
93N
IPNFZ
PSX
RIG
ID FETCH-LOGICAL-p615-b7b53f4cfca67eb8e5cc353d56b889b0d995df791bea8d03a8ab7619a8943bdd3
IEDL.DBID BENPR
ISSN 1001-5256
IngestDate Thu May 29 04:06:09 EDT 2025
Sat Aug 23 12:33:03 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords 预后
胆管炎
诊断
自身免疫性胰腺炎
治疗学
Language Chinese
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-p615-b7b53f4cfca67eb8e5cc353d56b889b0d995df791bea8d03a8ab7619a8943bdd3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
OpenAccessLink https://www.proquest.com/docview/3239774638?pq-origsite=%requestingapplication%&accountid=15518
PQID 3239774638
PQPubID 7350069
PageCount 5
ParticipantIDs wanfang_journals_lcgdbzz202104035
proquest_journals_3239774638
PublicationCentury 2000
PublicationDate 20210101
2021
PublicationDateYYYYMMDD 2021-01-01
PublicationDate_xml – month: 01
  year: 2021
  text: 20210101
  day: 01
PublicationDecade 2020
PublicationPlace Changchun
PublicationPlace_xml – name: Changchun
PublicationTitle Linchuang gandanbing zazhi
PublicationTitle_FL Journal of Clinical Hepatology
PublicationYear 2021
Publisher Journal of Clinical Hepatology
郑州大学第一附属医院消化内科,郑州450052
Publisher_xml – name: Journal of Clinical Hepatology
– name: 郑州大学第一附属医院消化内科,郑州450052
SSID ssib051369456
ssib061082477
ssj0041983
ssib001103858
ssib053243598
ssib002264326
ssib038074677
Score 2.225575
Snippet 目的 比较分析单纯自身免疫性胰腺炎(AIP)与AIP合并IgG4相关硬化性胆管炎(IgG4-SC)患者的临床特征差异、诊治和预后。 方法...
R576%R575.7; 目的 比较分析单纯自身免疫性胰腺炎(AIP)与AIP合并IgG4相关硬化性胆管炎(IgG4-SC)患者的临床特征差异、诊治和预后.方法...
SourceID wanfang
proquest
SourceType Aggregation Database
StartPage 888
SubjectTerms Cholangitis
Pancreatitis
Title 自身免疫性胰腺炎及其合并IgG4相关硬化性胆管炎的临床特征和预后比较
URI https://www.proquest.com/docview/3239774638
https://d.wanfangdata.com.cn/periodical/lcgdbzz202104035
Volume 37
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LaxRBEG6SLAlexCfGxCVCrmN6px_TcwiS1axRyCKSwJ4M_ZoVkc3DiLAnNVkfIcYgkoOe4kUwooISkj3k19iZ8V_YPTvjrhdvM3TRh6a6-qvqru8DYJz6WGrEtQcJp579ph63577nZI6hkkSExHUjz1bpzDy-VSO1PlDNe2Hcs8o8JqaBWi1KVyOfQH4KVay7XF1a9pxqlLtdzSU0eCatoCZTirF-ULAhmVm_L5Snq7fvdAFCCf7D3uLaSHsAjGNfxz0Eb6SEaIi7bDPEwg9HeZf_W-zB_LSTsxP7sU3hO0_6bZJOLJoYAuMuLw5pOHE_3dVX_g7Z3NQvpTSrTvqkB94OPuaNiDfqPedc5RQ4mQHUsamOR50Gfc17Z8DQbHYFfxbcTV58Ttp7pvU63tk7fvIpWfuetNrxsy3zZsO09s32S3O4f7N-A8cfDkzrR7z7xWzupHbP46-71i5-v_7r4Kdpb8SvDs3RU_N28_fHdbO9dfztXXK0dg7MVabnrs14mUiDt2TBkCcCQVCEZSQ5DbRgmkiJCFKECsZCAVUYEhUFYUlozhREnHHhKifc8b4LpdB5MNBYbOgLYAxqjUMMJbGQEkuBWKR9H0Y2g-aCUQmHwWi-SAvZRnu40HWLYXA5W7ju6ANZV6LZdCttgxUiF_8_xQg44Uw7FZZRMLC68khfsphjVRRBf1ALiqAwVb5erhQzt_oDAEnrJQ
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1NTxQxGG5wiejF-BlQ1DXB40hnpu1OD8T4Ae4KuzFmTTi56desMWZBwRD3pML6QRCJMRz0hBcTMWqiIbCJ_BrLLP_CdnbGXS_cuM2knR7ad973eds-zwvAEPGQUD5TDsSMOOaZOMzEfceWOYZSYE6xZSMXSyR_B92cxJM94HfKhbHXKlOfGDtqOSXsHvmw78VQxZjL5emHjq0aZU9X0xIaLCmtIEdiibGE2DGunsyZFG5mpHDdrPdFzxsbLV_LO0mVAWfaRHOH5zj2QyRCwUhO8UBhIXzsS0x4EFAOJaVYhjnqcsUCCX0WMG5Tf2aFy7mUvhn2AOhFluCaAb1XR0u3bnfwiAv_E4uxrNUuvGTF3lGXnhx2fUJRR9wGG7RjFfbSdwN1Ai8mjrZDDXJp0GYQQNdklJj0gSGbhlNCh-_HTuTSvyaTCnturOpqK610oemDc6wWslq1K6yOHQVHEjycvdI24GOgp37vOOgrJif-J8Dd1ssvrea6bryJVtd3nn5uzf9oNZrR82X9dlE3NvTKK721UajeQNHHTd34Ga191Uurcb8X0bc10y_6sPBn85duLkavt_T2M_1uaffTgl5Z3vn-vrU9fxKU92O1ToFMbaqm-kEWKoUoggIbBIsE94NQeR4MTcLOeEAEHACD6SRVkv96ptKxwgFwIZm4TusDUZW8XrczbXyjj0_vPcR5cChfLk5UJgql8TPgsP2svbkzCDKzjx6rswbuzPJziVFlQWWfzfgvJtYm1A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E8%87%AA%E8%BA%AB%E5%85%8D%E7%96%AB%E6%80%A7%E8%83%B0%E8%85%BA%E7%82%8E%E5%8F%8A%E5%85%B6%E5%90%88%E5%B9%B6IgG4%E7%9B%B8%E5%85%B3%E7%A1%AC%E5%8C%96%E6%80%A7%E8%83%86%E7%AE%A1%E7%82%8E%E7%9A%84%E4%B8%B4%E5%BA%8A%E7%89%B9%E5%BE%81%E5%92%8C%E9%A2%84%E5%90%8E%E6%AF%94%E8%BE%83&rft.jtitle=%E4%B8%B4%E5%BA%8A%E8%82%9D%E8%83%86%E7%97%85%E6%9D%82%E5%BF%97&rft.au=%E4%B8%81%E8%88%AA&rft.au=%E9%83%91%E7%90%B3%E7%90%B3&rft.au=%E5%88%98%E6%BA%90&rft.au=%E5%BC%A0%E8%BF%9E%E5%B3%B0&rft.date=2021&rft.pub=%E9%83%91%E5%B7%9E%E5%A4%A7%E5%AD%A6%E7%AC%AC%E4%B8%80%E9%99%84%E5%B1%9E%E5%8C%BB%E9%99%A2%E6%B6%88%E5%8C%96%E5%86%85%E7%A7%91%2C%E9%83%91%E5%B7%9E450052&rft.issn=1001-5256&rft.volume=37&rft.issue=4&rft.spage=888&rft.epage=892&rft_id=info:doi/10.3969%2Fj.issn.1001-5256.2021.04.032&rft.externalDocID=lcgdbzz202104035
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Flcgdbzz%2Flcgdbzz.jpg