ANTIBACTERIAL, ANTI-SWARMING POTENTIAL OF ETHANOL EXTRACTS OF PHYSALIS MINIMA L. WHOLE PLANT AND URENA LOBATA L. ROOT ON CEPHALOSPORIN RESISTANT PROTEUS SPECIES

• Published in: Global journal of research on medicinal plants and indigenous medicine Vol. 3; no. 5; p. 184
• Main Authors: Roshid, Mamunur, Chouduri, Aktar Uzzaman
• Format: Journal Article
• Language: English
• Published: Koppa Global Journal of Research on Medicinal Plants & Indigenous Medicine (GJRMI) 01.05.2014
• Subjects: Antibiotics; Antimicrobial agents; Asparagus; Azadirachta indica; Bacteria; Bacteriology; Drinking water; Drug resistance; E coli; Herbal medicine; Leaves; Medical research; Medicine; Microorganisms; Phyllanthus emblica; Physalis; Proteus; Studies; Tamarindus indica; Urena lobata; Urine
• ISSN: 2277-4289

This study aimed to search medicinal plants with high antibacterial potentials in order to manage antibiotic resistant uropathogens. Twelve specimens of nine medicinal plants which are available locally were analyzed for their anti-infective properties against resistant uropathogens using disc diffusion method. Remarkable antibacterial activities of ethanol extract of Physalis minima whole plant followed by Azadirachta indica leaf, Asparagus racemosus root, Phyllanthus emblica fruit, Urena lobata root and Tamarindus indica bark were found against eleven test bacteria and eleven resistant Proteus isolates. Physalis minima extract showed the highest zone of inhibition but it had no anti-swarming effect. Interestingly complete inhibition of swarming was found by Urena lobata root extract at 500 μg/ml concentration although its antibacterial activity was very low or nil. Thus, the mixture of two extracts would be a powerful anti-infective agent to combat UTI and/or wound infection caused by resistant Proteus bacteria. The extracts could be further analyzed for the drug development.