Synthesis, Characterization of Substituted 3-Cyanopyrroles and Evaluation of Antimicrobial Activity

A straightforward simple synthesis of substituted 3-cyanopyrroles using Paal-Knorr method has been accomplished with a satisfactory yield. The Paal-Knorr pyrrole synthesis, which involves the reaction of dicarbonyls with amines, is among the most classical methods of heterocyclic pyrrole ring synthe...

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Published inAsian Journal of Research in Chemistry Vol. 6; no. 11; p. 5
Main Authors Rajaram, Pawar Rupali, Krishna, Mohite Shrinivas
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 01.11.2013
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Summary:A straightforward simple synthesis of substituted 3-cyanopyrroles using Paal-Knorr method has been accomplished with a satisfactory yield. The Paal-Knorr pyrrole synthesis, which involves the reaction of dicarbonyls with amines, is among the most classical methods of heterocyclic pyrrole ring synthesis. The detailed sequence and the nature of the intermediates that occur in the Paal-Knorr reaction mechanism are not well understood. This method produces pyrroles with multicyclic aromatic amines. A series of substituted 3-cyanopyrrole derivatives were evaluated for anti-inflammatory and antimicrobial activity. [PUBLICATION ABSTRACT]
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ISSN:0974-4169
0974-4150