Controlling Pre-leukemic Thymocyte Self-Renewal e1004881

Interestingly, combined SCL and LMO1 overexpression was sufficient to reprogram double negative 3 (DN3) T cell precursors with a finite lifespan into pre-LSCs with self-renewal activity and retained differentiation capacity (Fig. 1). [...]transcriptome analysis revealed that this transition towards...

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Bibliographic Details
Published inPLoS genetics Vol. 10; no. 12
Main Authors Goossens, Steven, Vlierberghe, Pieter Van
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 01.12.2014
Subjects
Acquisitions & mergers
Gene expression
Leukemia
Lymphocytes
Mutation
Pathogenesis
Physiology
Proteins
Rodents
Stem cells
Transcription factors
United States > US
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Summary:Interestingly, combined SCL and LMO1 overexpression was sufficient to reprogram double negative 3 (DN3) T cell precursors with a finite lifespan into pre-LSCs with self-renewal activity and retained differentiation capacity (Fig. 1). [...]transcriptome analysis revealed that this transition towards pre-LSC was accompanied by a marked up-regulation of a stem cell signature, including Hhex, Nfe2, and Lyl1. [...]chromosomal translocations or small genomic deletions targeting SCL, LYL1, and/or LMO2, are exclusively present in primary human T-ALLs with a late cortical tumor phenotype [1]. [...]the functional role of SCL, LYL1, and/or LMO2 in regulating self-renewal capacity might be influenced by the immunophenotypic background of the different molecular-genetic subtypes of human T-ALL, a notion that could be tested using transgenic models that overexpress the specific members of this bHLH transcription complex at later stages during T cell development.
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ISSN:1553-7390
1553-7404
DOI:10.1371/journal.pgen.1004881