PLA2R和IgG4对老年原发性膜性肾病的诊断价值

• Published in: Jie fang jun yi xue za zhi Vol. 42; no. 9; pp. 810 - 814
• Main Authors: Wen-ming, YUAN, Gen-yang, CHENG, Yan-sheng, LI, LIU, Dong, XIAO, Jing, Yan-nan DOU, Zhan-zheng, ZHAO
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.01.2017; 450052,郑州 郑州大学第一附属医院肾脏内科
• Subjects: 膜性肾病; 诊断; ROC曲线; diagnose; ROC curve; membranous nephropathy; PLA2R
• ISSN: 0577-7402
• DOI: 10.11855/j.issn.0577-7402.2017.09.11

Objective To evaluate the diagnostic significance of PLA2R and IgG4 in elderly patients with idiopathic membranous nephropathy (IMN). Methods The clinical data were retrospectively analyzed of patients with IMN (49 males and 49 females, aged 66.6±5.4 years) or Non-IMN (57 males and 41 females, aged 67.1±6.5 years) who were admitted in the authors served Department of Nephrology from Apr. 2014 to Feb. 2016 and accepted renal biopsy. SPSS13.0 was employed to evaluate the sensitivity, specificity and calculate the area under ROC curve (AUC) of serum anti-PLA2R antibody, glomerular PLA2R and IgG1-4 subclasses on diagnosing IMN. Results On diagnosing IMN, the sensitivity and specificity of serum anti-PLA2R antibody were 77.6% and 89.8% [AUC=0.869(0.816-0.923)], of glomerular PLA2R were 66.3% and 94.9% [AUC=0.805(0.741- 0.87)], and of glomerular IgG1-IgG4 were 80.6% and 78.6%, 60.2% and 83.7%, 41.8% and 84.7%, and 93.9% and 89.8%, respectively [AUC=0.767(0.696-0.838), 0.709(0.635-0.783), 0.628(0.549-0.706) and 0.94