Changes in the urinary proteome in a Patient-Derived Xenograft model

In this report, the urinary proteome from a patient-derived xenograft (PDX) model was compared at the peptide level to study the origins of urinary proteins in tumor-bearing nude mice. Urine was collected from the PDX mice before and after tumor implantation. A total of 515 mouse proteins were ident...

Full description

Saved in:
Bibliographic Details
Published inbioRxiv
Main Authors Liu, Yongtao, Wang, Youzhu, Cao, Zhixiang, Gao, Youhe
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 10.07.2018
Subjects
Immune response
Proteins
Proteomes
Urine
Xenografts
Online AccessGet full text

Cover

More Information
Summary:In this report, the urinary proteome from a patient-derived xenograft (PDX) model was compared at the peptide level to study the origins of urinary proteins in tumor-bearing nude mice. Urine was collected from the PDX mice before and after tumor implantation. A total of 515 mouse proteins were identified, of which 8 were differential proteins. Seventy-eight unambiguous human peptides from 42 human proteins were identified in the tumor-bearing group. Compared with the differential urinary proteins from the tumor-bearing immuno-competent rats, the differential proteins in the urine from the PDX model had no host immune response proteins in the very early stage urine in the tumor-bearing immuno-competent rat model.
DOI:10.1101/365999