Transcriptomic atlas of mushroom development highlights an independent origin of complex multicellularity

We constructed a reference atlas of mushroom formation based on developmental transcriptome data of six species and comparisons of >200 whole genomes, to elucidate the core genetic program of complex multicellularity and fruiting body development in mushroom-forming fungi (Agaricomycetes). Nearly...

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Published inbioRxiv
Main Authors Krizsan, Krisztina, Almasi, Eva, Merenyi, Zsolt, Sahu, Neha, Mate Viragh, Koszo, Tamas, Mondo, Stephen, Kiss, Brigitta, Balint, Balazs, Kues, Ursula, Barry, Kerrie, Cseklye, Judit, Hegedus, Botond, Henrissat, Bernard, Johnson, Jenifer, Lipzen, Anna, Ohm, Robin A, Nagy, Istvan, Pangilinan, Jasmyn, Yan, Juying, Xiong, Yi, Grigoriev, Igor V, Hibbett, David S, Nagy, Laszlo G
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 18.06.2018
Subjects
Biodegradation
Cadherins
Cell walls
Fruit bodies
Fungi
Gene families
Genomes
Mushrooms
Protein kinase
Proteins
Signal transduction
Transduction
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Summary:We constructed a reference atlas of mushroom formation based on developmental transcriptome data of six species and comparisons of >200 whole genomes, to elucidate the core genetic program of complex multicellularity and fruiting body development in mushroom-forming fungi (Agaricomycetes). Nearly 300 conserved gene families and >70 functional groups contained developmentally regulated genes from five to six species, covering functions related to fungal cell wall (FCW) remodeling, targeted protein degradation, signal transduction, adhesion and small secreted proteins (including effector-like orphan genes). Several of these families, including F-box proteins, protein kinases and cadherin-like proteins, showed massive expansions in Agaricomycetes, with many convergently expanded in multicellular plants and/or animals too, reflecting broad genetic convergence among independently evolved complex multicellular lineages. This study provides a novel entry point to studying mushroom development and complex multicellularity in one of the largest clades of complex eukaryotic organisms.
DOI:10.1101/349894