Correlation between polymorphism of ACE gene I/D and ACE2 gene A9570G and atrial fibrillation

• Published in: Jie fang jun yi xue za zhi Vol. 36; no. 9; pp. 904 - 908
• Main Authors: Ya-zhu, WANG, LI, Ying, Jin-qi, FAN, Yan-ping, XU, Pei-lin, XIAO, LONG, Yi, Zhi-yu, LIN, Zhi-feng, LI, Yue-hui, YIN
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.09.2011
• Subjects: Cardiac arrhythmia; Cardiovascular disease; Electrocardiography; Enzymes; Males
• ISSN: 0577-7402

Objective To investigate the correlation between the polymorphism of angiotensin converting enzyme(ACE) gene I/D and angiotensin converting enzyme 2(ACE2) gene A9570G and atrial fibrillation.Methods In chronological order of hospitalization,305 patients were selected and divided into two groups: atrial fibrillation group(148 cases) and control group(157cases without atrial fibrillation).The control group was matched with the atrial fibrillation group in terms of age,gender,and presence of left ventricular dysfunction,coronary heart disease,diabetes,and primary hypertension.The polymorphisms of the ACE gene I/D and ACE2 gene A9570G were genotyped with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and gene sequencing approach.Results There were no statistical differences between the atrial fibrillation group and the control group in genotype distribution and allele frequencies of the ACE gene I/D(P=0.841;OR=0.948,95% CI 0.680-1.322,P=0.755).Moreover,there was no significant differ