Experimental paracoccidiodomycosis of hamsters and mice : treatment with a new triazole Sch 39304

The triazole Sch 39304 was compared with itraconazole and ketoconazole in the treatment of experimental paracoccidioidomycosis in mice and hamsters. In the hamster model, ketoconazole at 80 mg/kg, itraconazole at 10 and 20 mg/kg and Sch 39304 at 10 mg/kg were equally effective. In the mouse model, k...

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Published inRevista iberoamericana de micología Vol. 9; no. 3; pp. 72 - 75
Main Authors REZKALLAH-IWASSO, M. T, VILLAS BOAS, M. L. F, SOARES, A, FRANCO, M, SUGIZAKI, M. F, FECCHIO, D, PERACOLI, M. T
Format Journal Article
LanguageEnglish
Spanish
Published Barcelona Asociación Española de Especialistas en Micología 1992
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Paracoccidioides brasiliensis
Pharmacology. Drug treatments
Animal model
Blastomycosis
Triazole
Mycosis
Rodentia
Infection
Vertebrata
Antifungal agent
Mammalia
Guinea pig
Treatment
Mouse
Paracoccidioidomycosis
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Summary:The triazole Sch 39304 was compared with itraconazole and ketoconazole in the treatment of experimental paracoccidioidomycosis in mice and hamsters. In the hamster model, ketoconazole at 80 mg/kg, itraconazole at 10 and 20 mg/kg and Sch 39304 at 10 mg/kg were equally effective. In the mouse model, ketoconazole at 100 mg/kg and Sch 39304 at 10 mg/kg were effective in controlling the infection. In both models only Sch 39304 at 10 mg/kg achieved sterilization of the infectious foci.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1130-1406