Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a betaARK inhibitor

Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (betaARK1) or a betaARK inhibitor. Because increased amounts of betaARK1 and diminished cardiac beta-adrenergic responsiveness characterize heart failure, these animals may provide experimental...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 268; no. 5215; p. 1350
Main Authors Koch, Walter J, Rockman, Howard A, Samama, Philippe, Hamilton, RaeAnn
Format Journal Article
LanguageEnglish
Published Washington The American Association for the Advancement of Science 02.06.1995
Subjects
Animals
Cardiovascular disease
Cellular biology
Coding
Desensitization
Medical research
Rodents
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Summary:Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (betaARK1) or a betaARK inhibitor. Because increased amounts of betaARK1 and diminished cardiac beta-adrenergic responsiveness characterize heart failure, these animals may provide experimental models to study the role of betaARK in heart disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0036-8075
1095-9203