Hyperkalemic Periodic Paralysis and the Adult Muscle Sodium Channel (Alpha)-Subunit Gene

Hyperkalemic periodic paralysis (HYPP) is an autosomal dominant disorder characterized by episodes of muscle weakness due to depolarization of the muscle cell membrane associated with elevated serum potassium. Portions of the adult muscle sodium channel alpha-subunit gene were cloned and mapped, ind...

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Published inScience (American Association for the Advancement of Science) Vol. 250; no. 4983; p. 1000
Main Authors Fontaine, Bertrand, Khurana, Tejvir S, Hoffman, Eric P, Bruns, Gail A P, Haines, Jonathan L
Format Journal Article
LanguageEnglish
Published Washington The American Association for the Advancement of Science 16.11.1990
Subjects
Genetics
Medical disorders
Medical research
Muscular system
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Summary:Hyperkalemic periodic paralysis (HYPP) is an autosomal dominant disorder characterized by episodes of muscle weakness due to depolarization of the muscle cell membrane associated with elevated serum potassium. Portions of the adult muscle sodium channel alpha-subunit gene were cloned and mapped, indicating the likelihood that the gene contains the HYPP mutation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0036-8075
1095-9203