Go is a major growth cone protein subject to regulation by GAP-43

G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-y-S binding to G0. It does so through...

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Bibliographic Details
Published inNature (London) Vol. 344; no. 6269; pp. 836 - 841
Main Authors STRITTMATTER, S. M, VALENZUELA, D, KENNEDY, T. E, NEER, E. J, FISHMAN, M. C
Format Journal Article
LanguageEnglish
Published London Nature Publishing 26.04.1990
Nature Publishing Group
Subjects
Analytical, structural and metabolic biochemistry
Animal behavior
Binding and carrier proteins
Biological and medical sciences
Chromatography
Fundamental and applied biological sciences. Psychology
GAP-43 protein
GTP-binding protein
Homology
Intracellular
Kinases
Peptides
Proteins
Receptors
Science
Brain
Cone
Rat
Rodentia
HPLC chromatography
Binding protein
Vertebrata
Regulation(control)
Mammalia
Neuron
Plasma membrane
Immunofluorescence
Immunoelectrophoresis
Aminoacid sequence
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Summary:G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-y-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0 in the growth cone may be regulated by intracellular as well as extracellular signals.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:0028-0836
1476-4687
DOI:10.1038/344836a0