The GABA^sub A^ receptor: a novel target for treatment of fragile X?

... receptors are the major inhibitory neurotransmitter receptors in the mammalian brain, implicated in anxiety, depression, epilepsy, insomnia, and learning and memory. Here, we present several lines of evidence for involvement of the GABAergic system, and in particular the ... receptor-mediated fu...

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Published inTrends in neurosciences (Regular ed.) Vol. 30; no. 8; pp. 425 - 431
Main Authors D'Hulst, Charlotte, Kooy, R Frank
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Sequoia S.A 01.08.2007
Subjects
Brain
Genetics
Mental disorders
Neurology
Neurotransmitters
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Summary:... receptors are the major inhibitory neurotransmitter receptors in the mammalian brain, implicated in anxiety, depression, epilepsy, insomnia, and learning and memory. Here, we present several lines of evidence for involvement of the GABAergic system, and in particular the ... receptor-mediated function, in fragile X syndrome, the most common form of inherited mental retardation. We argue that an altered expression of the ... receptor has neurophysiologic and functional consequences that might relate to the behavioural and neurological phenotype associated with fragile X syndrome. Interestingly, some neuropsychiatric disorders, such as anxiety, epilepsy and sleep disorders, are effectively treated with therapeutic agents that act on the ...receptor. Therefore, the ... receptor might be a novel therapeutic target for fragile X syndrome. (ProQuest-CSA LLC: ... denotes formulae/symbols omitted.)
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2007.06.003