Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats

The goal of these studies was to investigate the mechanisms by which amino acid supply regulates global rates of protein synthesis as well as the translation of ribosomal protein (rp) mRNAs in liver. In the experiments conducted, male weanling rats were trained over a 2-wk period to consume their da...

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Published inAmerican journal of physiology: endocrinology and metabolism Vol. 44; no. 3; pp. E430 - E439
Main Authors ANTHONY, Tracy G, REITER, Ali K, ANTHONY, Joshua C, KIMBALL, Scot R, JEFFERSON, Leonard S
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.09.2001
Subjects
Amino acids
Biological and medical sciences
Cellular biology
Diet
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Liver
Proteins
Ribonucleic acid
RNA
Rodents
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Rat
Digestive system
Deficiency
Liver
Rodentia
Essential
Genetic translation
Feeding
Vertebrata
Mammalia
Protein synthesis
Aminoacid
Restricted diet
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Summary:The goal of these studies was to investigate the mechanisms by which amino acid supply regulates global rates of protein synthesis as well as the translation of ribosomal protein (rp) mRNAs in liver. In the experiments conducted, male weanling rats were trained over a 2-wk period to consume their daily food intake within 3 h.
ISSN:0193-1849
1522-1555