Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule

We examined the rat proximal tubule (PT) response to endothelin-1 (ET-1) in terms of 20-hydroxyeicosatetraenoic acid (HETE) dependency. Arachidonic acid (AA) (1 muM) decreased ouabain-sensitive (86)Rb uptake from 2.1 +/- 0.1 to 0.3 +/- 0.08 ng Rb-10 mug protein (-1)-2 min(-1) (P < 0.05); 20-HETE...

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Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 51; no. 1; pp. F144 - F150
Main Authors ESCALANTE, Bruno A, MCGIFF, John C, OYEKAN, Adebayo O
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 2002
Subjects
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Kidneys
Metabolism
Rodents
Vertebrates: urinary system
Rat
Metabolite
Cytochrome P450
Rodentia
Ion transport
Molecular interaction
Endothelin 1
Arachidonic acid
Kidney
Biological activity
HETE
Vertebrata
Mammalia
Urinary system
Animal
Eicosanoid
Proximal tube
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Summary:We examined the rat proximal tubule (PT) response to endothelin-1 (ET-1) in terms of 20-hydroxyeicosatetraenoic acid (HETE) dependency. Arachidonic acid (AA) (1 muM) decreased ouabain-sensitive (86)Rb uptake from 2.1 +/- 0.1 to 0.3 +/- 0.08 ng Rb-10 mug protein (-1)-2 min(-1) (P < 0.05); 20-HETE (1 muM) had similar effects.
ISSN:1931-857X
1522-1466