High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men

There is evidence that gastrointestinal function adapts in response to a high-fat (HF) diet. This study investigated the hypothesis that an HF diet modifies the acute effects of duodenal lipid on appetite, antropyloroduodenal pressures, plasma CCK and plasma glucagon-like peptide-1 (GLP-1) levels in...

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Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 47; no. 2; pp. G188 - G196
Main Authors BOYD, K. A, O'DONOVAN, D. G, DORAN, S, WISHART, J, CHAPMAN, I. M, HOROWITZ, M, FEINLE, C
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.02.2003
Subjects
Biological and medical sciences
Diet
Fundamental and applied biological sciences. Psychology
General aspects
Lipids
Men
Peptides
Small intestine
Vertebrates: digestive system
Appetite
Human
energy intake
Feeding behavior
Motility
Duodenum
Digestive system
Lipids
Supplemented diet
Small intestine
Neuropeptide
Feeding
Glucagon like peptide 1
Endocrine secretion
Gastrointestinal hormone
glucose-like peptide-1
Food intake
Cholecystokinin
Macronutrient
antropyloroduodenal pressures
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Summary:There is evidence that gastrointestinal function adapts in response to a high-fat (HF) diet. This study investigated the hypothesis that an HF diet modifies the acute effects of duodenal lipid on appetite, antropyloroduodenal pressures, plasma CCK and plasma glucagon-like peptide-1 (GLP-1) levels in humans. Twelve healthy men were studied twice in randomized, crossover fashion. The effects of a 90-min duodenal lipid infusion (6.3 kJ/min) on the above parameters were assessed immediately following 14-day periods on either an HF or a low-fat (LF) diet. After the HF diet, pyloric tonic and phasic pressures were attenuated, and the number of antropyloroduodenal pressure-wave sequences was increased when compared with the LF diet. Plasma CCK and GLP-1 levels did not differ between the two diets. Hunger was greater during the lipid infusion following the HF diet, but there was no difference in food intake. Therefore, exposure to an HF diet for 14 days attenuates the effects of duodenal lipid on antropyloroduodenal pressures and hunger without affecting food intake or plasma hormone levels.
ISSN:0193-1857
1522-1547