An NAD(P)H oxidase regulates growth and transcription in melanoma cells

Although antioxidants and inhibitors of NAD(P)H oxidases significantly reduce constitutive nuclear factor-KB (NF-KB) activation and suppress cell proliferation, the nature of the enzyme responsible for reactive oxygen species (ROS) production in melanoma cells has not been determined. To address thi...

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Published inAmerican Journal of Physiology: Cell Physiology Vol. 51; no. 6; pp. C1212 - C1224
Main Authors BRAR, Sukhdev S, KENNEDY, Thomas P, STURROCK, Anne B, HUECKSTEADT, Thomas P, QUINN, Mark T, WHORTON, A. Richard, HOIDAL, John R
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.06.2002
Subjects
Biological and medical sciences
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Cellular biology
Enzymes
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Tumors
Human
Cell proliferation
Oxygen
Transcription
Growth
Melanoma
Activation
Antioxidant
Gene expression
Response element
Free radical
NAD(P)H oxidase
Signal transduction
Transcription factor NFκB
Tumor cell
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Summary:Although antioxidants and inhibitors of NAD(P)H oxidases significantly reduce constitutive nuclear factor-KB (NF-KB) activation and suppress cell proliferation, the nature of the enzyme responsible for reactive oxygen species (ROS) production in melanoma cells has not been determined. To address this issue, Brar et al characterized the source of ROS production in melanoma cells.
ISSN:0363-6143
1522-1563