Potassium channel expression level is dependent on the proliferation state in the GH3 pituitary cell line

Using cell synchronization, we show here that Ito drops precisely at the quiescent (G0 phase)/proliferating transition. These results provide new evidence for the cell cycle dependence of Ito expression, which could be relevant in understanding the mechanisms leading to pituitary adenomas. [PUBLICAT...

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Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 53; no. 4; pp. C1054 - C1064
Main Authors CZARNECKI, Antonny, DUFY-BARBE, Luce, HUET, Sylvie, ODESSA, Marie-Francoise, BRESSON-BEPOLDIN, Laurence
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.04.2003
Subjects
Biological and medical sciences
Cellular biology
Fundamental and applied biological sciences. Psychology
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Morphology. Functional localizations
Pituitary gland
Potassium
Vertebrates: endocrinology
Cell proliferation
Endocrine gland
Rat
Potassium ion
Rodentia
Electrophysiology
Ionic channel
Ionic current
Excitable membrane
Outward current
Vertebrata
Mammalia
Animal
Cell cycle
Established cell line
Pituitary gland
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Summary:Using cell synchronization, we show here that Ito drops precisely at the quiescent (G0 phase)/proliferating transition. These results provide new evidence for the cell cycle dependence of Ito expression, which could be relevant in understanding the mechanisms leading to pituitary adenomas. [PUBLICATION ABSTRACT]
ISSN:0363-6143
1522-1563