Temperature dependence of cloned mammalian and salmonid cardiac Na+/Ca2+ exchanger isoforms

The cardiac Na+/Ca(2+) exchanger (NCX), an important regulator of cytosolic Ca(2+) concentration in contraction and relaxation, has been shown in trout heart sarcolemmal vesicles to have high activity at 7degreesC relative to its mammalian isoform. This unique property is likely due to differences i...

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Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 50; no. 3; pp. C993 - C1000
Main Authors ELIAS, Chadwick L, XUE, Xiao-Hua, MARSHALL, Christian R, OMELCHENKO, Alexander, HRYSHKO, Larry V, TIBBITS, Glen F
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.09.2001
Subjects
Biological and medical sciences
Calcium
Cardiology
Cell physiology
Cloning
Fish
Fundamental and applied biological sciences. Psychology
Ions
Mammals
Membrane and intracellular transports
Molecular and cellular biology
Sodium
Temperature
Salmonidae
Molecular form
Temperature
Calcium
Ion transport
Coupled transport
Ionic current
Gene expression
In vitro
Vertebrata
Mammalia
Na
Sodium
Membrane transport
Pisces
exchanger
Ion exchanger
Comparative study
Carrier protein
Ca
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Summary:The cardiac Na+/Ca(2+) exchanger (NCX), an important regulator of cytosolic Ca(2+) concentration in contraction and relaxation, has been shown in trout heart sarcolemmal vesicles to have high activity at 7degreesC relative to its mammalian isoform. This unique property is likely due to differences in protein structure.
ISSN:0363-6143
1522-1563