Opposing gates model for voltage gating of gap junction channels

Gap junctions are intecellular channels that link the cytoplasm of neighboring cells. Because a gap junction channel is composed of two connexons docking head-to-head with each other, the channel voltage-gating profile is symmetrical for homotypic channels made of two identical connexons (hemichanne...

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Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 50; no. 5; pp. C1604 - C1613
Main Authors CHEN-IZU, Ye, MORENO, Alonso P, SPANGLER, Robert A
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.11.2001
Subjects
Biological and medical sciences
Cell membranes. Ionic channels. Membrane pores
Cell structures and functions
Cells
Fundamental and applied biological sciences. Psychology
Mathematical models
Molecular and cellular biology
Connexin
Electrophysiology
Cell junction
Electrical conductance
Membrane potential
Membrane channel
Gene expression
Mathematical model
Gating
In vitro
Gap junction
Oocyte
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Summary:Gap junctions are intecellular channels that link the cytoplasm of neighboring cells. Because a gap junction channel is composed of two connexons docking head-to-head with each other, the channel voltage-gating profile is symmetrical for homotypic channels made of two identical connexons (hemichannels) and asymmetric for the heterotypic channels made of two different connexons (i.e., different connexin composition).
ISSN:0363-6143
1522-1563