Regulation of oligopeptide transporter (Pept-1) in experimental diabetes

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 46; no. 1; pp. G133 - G138
• Main Authors: GANGOPADHYAY, Archana, THAMOTHARAN, Manikkavasagar, ADIBI, Siamak A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.07.2002
• Subjects: Biological and medical sciences; Diabetes; Diabetes. Impaired glucose tolerance; Digestive system; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Genes; Medical sciences; Membranes; Peptides; Endocrinopathy; Oligopeptides; Pathophysiology; Rat; Transcription; Digestive system; Diabetes mellitus; Rodentia; Gut; Gene expression; Kidney; Vertebrata; Brush border; Experimental disease; Regulation(control); Mammalia; Urinary system; Animal; Plasma membrane; Carrier protein
• ISSN: 0193-1857

The knowledge of expression and biology of the intestinal oligopeptide transporter (Pept-1) in a metabolic disorder such as diabetes may have nutritional and pharmacological implications. To study this problem, rats were made diabetic by streptozotocin injection, and Western and Northern blot analyses and nuclear run-on assay were used to determine the protein and gene expression of Pept-1 and its rate of transcription, respectively.