Regulation of oligopeptide transporter (Pept-1) in experimental diabetes

The knowledge of expression and biology of the intestinal oligopeptide transporter (Pept-1) in a metabolic disorder such as diabetes may have nutritional and pharmacological implications. To study this problem, rats were made diabetic by streptozotocin injection, and Western and Northern blot analys...

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Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 46; no. 1; pp. G133 - G138
Main Authors GANGOPADHYAY, Archana, THAMOTHARAN, Manikkavasagar, ADIBI, Siamak A
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.07.2002
Subjects
Biological and medical sciences
Diabetes
Diabetes. Impaired glucose tolerance
Digestive system
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Genes
Medical sciences
Membranes
Peptides
Endocrinopathy
Oligopeptides
Pathophysiology
Rat
Transcription
Digestive system
Diabetes mellitus
Rodentia
Gut
Gene expression
Kidney
Vertebrata
Brush border
Experimental disease
Regulation(control)
Mammalia
Urinary system
Animal
Plasma membrane
Carrier protein
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Summary:The knowledge of expression and biology of the intestinal oligopeptide transporter (Pept-1) in a metabolic disorder such as diabetes may have nutritional and pharmacological implications. To study this problem, rats were made diabetic by streptozotocin injection, and Western and Northern blot analyses and nuclear run-on assay were used to determine the protein and gene expression of Pept-1 and its rate of transcription, respectively.
ISSN:0193-1857
1522-1547