Regulation of renal cortical cyclooxygenase-2 in young rats

Cyclooxygenase-2 (COX-2) is involved in kidney morphogenesis and is transiently elevated in the immature kidney. In adult rats, renal cortical COX-2 expression is tonically suppressed by mineralocorticoids (MC) and glucocorticoids (GC) and induced by chronic salt restriction. Young rats have low lev...

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Published inAmerican journal of physiology. Renal physiology Vol. 54; no. 5; pp. F881 - F888
Main Authors ZHANG, Ming-Zhi, WANG, Su-Wan, HUIFANG CHENG, YAHUA ZHANG, MCKANNA, James A, HARRIS, Raymond C
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.11.2003
Subjects
Biological and medical sciences
Cyclin-dependent kinases
Fundamental and applied biological sciences. Psychology
Kidneys
Rodents
Vertebrates: urinary system
Prostaglandin-endoperoxide synthase
Rat
salt supplementation
Enzyme
Mineralocorticoid
Rodentia
Supplemented diet
Gene expression
Inorganic element
Glucocorticoid
Kidney
Young animal
Feeding
Micronutrient
Salt
Vertebrata
Regulation(control)
Mammalia
Urinary system
Enzymatic activity
Oxidoreductases
Supplementation
Renal cortex
prostaglandin synthase G2/H2
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Summary:Cyclooxygenase-2 (COX-2) is involved in kidney morphogenesis and is transiently elevated in the immature kidney. In adult rats, renal cortical COX-2 expression is tonically suppressed by mineralocorticoids (MC) and glucocorticoids (GC) and induced by chronic salt restriction. Young rats have low levels of GC and are in a state of relative volume depletion. The present study was designed to investigate the mechanisms underlying elevated cortical COX-2 expression in the immature kidney. Supplementation of GC or MC suppressed cortical COX-2 expression in suckling rats. GC suppression was significantly, but not completely, prevented by either an MC receptor antagonist or a GC receptor antagonist. MC suppression was completely prevented by a mineralocorticoid receptor antagonist. Salt supplementation suppressed cortical COX-2 expression in a dose- and time-dependent pattern in the suckling rats. Cortical COX-2 expression in the weanling rats was upregulated by a low-salt diet and downregulated by a high-salt diet. These results suggest that relative volume depletion and reduced GC levels are involved in elevated cortical COX-2 expression in the immature rodent kidney. [PUBLICATION ABSTRACT]
ISSN:1931-857X
1522-1466