Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

The underlying mechanism by which skeletal muscle adapts to exercise training or chronic energy deprivation is largely unknown. To examine this question, rats were fed for 9 wk either with or without beta-guanadinopropionic acid (beta-GPA; 1% enriched diet), a creatine analog that is known to induce...

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Bibliographic Details
Published inAmerican journal of physiology: endocrinology and metabolism Vol. 44; no. 6; pp. E1340 - E1349
Main Authors BERGERON, Raynald, JIAN MING REN, CADMAN, Kevin S, MOORE, Irene K, PERRET, Pascale, PYPAERT, Marc, YOUNG, Lawrence H, SEMENKOVICH, Clay F, SHULMAN, Gerald I
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.12.2001
Subjects
Biological and medical sciences
Enzymes
Exercise
Fundamental and applied biological sciences. Psychology
Proteins
Respiratory system
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
Activation
Striated muscle
Enzyme
Kinase
Transferases
Adaptation
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Summary:The underlying mechanism by which skeletal muscle adapts to exercise training or chronic energy deprivation is largely unknown. To examine this question, rats were fed for 9 wk either with or without beta-guanadinopropionic acid (beta-GPA; 1% enriched diet), a creatine analog that is known to induce muscle adaptations similar to those induced by exercise training.
ISSN:0193-1849
1522-1555