Anti-adrenergic effects of nitric oxide donor SIN-1 in rat cardiac myocytes

We studied how the nitric oxide (NO) donor 3-morpholinosydnonimine (SIN-1) alters the response to beta-adrenergic stimulation in cardiac rat myocytes. We found that SIN-1 decreases the positive inotropic effect of isoproterenol (Iso) and decreases the extent of both cell shortening and Ca2+ transien...

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Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 50; no. 1; pp. C342 - C349
Main Authors STOJANOVIC, Miroslav O, ZIOLO, Mark T, WAHLER, Gordon M, WOLSKA, Beata M
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.07.2001
Subjects
Biochemistry
Biological and medical sciences
Cell physiology
Cells
Fundamental and applied biological sciences. Psychology
Gases
Heart
Molecular and cellular biology
Muscle contraction
Pathology
Rodents
Heart
Phosphorylation
Calcium
Rat
Enzyme
Rodentia
Superoxide dismutase
Phospholamban
Muscle contraction
In vitro
Myocyte
β-Adrenergic receptor
Signal transduction
Vertebrata
Troponin
Mammalia
Peroxidases
Catalase
Circulatory system
Oxidoreductases
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Summary:We studied how the nitric oxide (NO) donor 3-morpholinosydnonimine (SIN-1) alters the response to beta-adrenergic stimulation in cardiac rat myocytes. We found that SIN-1 decreases the positive inotropic effect of isoproterenol (Iso) and decreases the extent of both cell shortening and Ca2+ transient.
ISSN:0363-6143
1522-1563