H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1

Knutter et al describe for the first time the presence of H+-peptide cotransport in cells of the bile duct. Uptake of [glycine-1-14C]glycylsarcosine ([14C]Gly-Sar) in human extrahepatic cholangiocarcinoma SK-ChA-1 cells was stimulated sevenfold by an inwardly directed H+ gradient.

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Bibliographic Details
Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 46; no. 1; pp. G222 - G229
Main Authors KNÜTTER, Ilka, RUBIO-ALIAGA, Isabel, BOLL, Michael, HAUSE, Gerd, DANIEL, Hannelore, NEUBERT, Klaus, BRANDSCH, Matthias
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.07.2002
Subjects
Bile
Biological and medical sciences
Cells
Digestive system
Fundamental and applied biological sciences. Psychology
Liver. Bile. Biliary tracts
Membranes
Peptides
Vertebrates: digestive system
Human
Cell line
Peptides
Extrahepathic bile duct
Digestive system
Membrane transport
Proton
Epithelial cell
In vitro
Carrier protein
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Summary:Knutter et al describe for the first time the presence of H+-peptide cotransport in cells of the bile duct. Uptake of [glycine-1-14C]glycylsarcosine ([14C]Gly-Sar) in human extrahepatic cholangiocarcinoma SK-ChA-1 cells was stimulated sevenfold by an inwardly directed H+ gradient.
ISSN:0193-1857
1522-1547