Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS

We hypothesized that short-term calorie restriction would blunt luteinizing hormone (LH) hypersecretion in obese women with polycystic ovary syndrome (PCOS) and thereby ameliorate the anovulatory endocrine milieu. To test this hypothesis, 15 obese patients with PCOS and nine age- and body mass index...

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Published inAmerican journal of physiology: endocrinology and metabolism Vol. 45; no. 4; pp. E865 - E872
Main Authors VAN DAM, Eveline W. C. M, ROELFSEMA, Ferdinand, VELDHUIS, Johannes D, HELMERHORST, Frans M, FRÖLICH, Marijke, MEINDERS, A. Edo, KRANS, H. Michiel J, PIJL, Hanno
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.04.2002
Subjects
Biological and medical sciences
Clinical trials
Diet
Metabolism
Obesity
Pituitary gland
Women
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Summary:We hypothesized that short-term calorie restriction would blunt luteinizing hormone (LH) hypersecretion in obese women with polycystic ovary syndrome (PCOS) and thereby ameliorate the anovulatory endocrine milieu. To test this hypothesis, 15 obese patients with PCOS and nine age- and body mass index-matched healthy women underwent 24-h blood sampling to quantitate plasma LH, leptin, and insulin levels.
ISSN:0193-1849
1522-1555