Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle
Amino acids and insulin have anabolic effects in skeletal muscle, but the mechanisms are poorly understood. To test the hypothesis that leucine and insulin stimulate translation initiation in human skeletal muscle by phosphorylating 70-kDa ribosomal protein S6 kinase (p70(S6k)), we infused healthy a...
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| Published in | American journal of physiology: endocrinology and metabolism Vol. 44; no. 3; pp. E466 - E471 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bethesda, MD
American Physiological Society
01.09.2001
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Amino acids and insulin have anabolic effects in skeletal muscle, but the mechanisms are poorly understood. To test the hypothesis that leucine and insulin stimulate translation initiation in human skeletal muscle by phosphorylating 70-kDa ribosomal protein S6 kinase (p70(S6k)), we infused healthy adults with leucine along (n=6), insulin alone (n=6), or both leucine and insulin (n=6) for 2 h. |
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| AbstractList | Amino acids and insulin have anabolic effects in skeletal muscle, but the mechanisms are poorly understood. To test the hypothesis that leucine and insulin stimulate translation initiation in human skeletal muscle by phosphorylating 70-kDa ribosomal protein S6 kinase (p70(S6k)), we infused healthy adults with leucine along (n=6), insulin alone (n=6), or both leucine and insulin (n=6) for 2 h. |
| Author | GUIM KWON GREIWE, Jeffrey S MCDANIEL, Michael L SEMENKOVICH, Clay F |
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| Keywords | Human Pancreatic hormone Enzyme Kinase Protein synthesis Transferases Aminoacid Leucine Striated muscle Insulin |
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| SubjectTerms | Amino acids Biological and medical sciences Fundamental and applied biological sciences. Psychology Insulin Muscular system Proteins Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| Title | Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle |
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