Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle

Amino acids and insulin have anabolic effects in skeletal muscle, but the mechanisms are poorly understood. To test the hypothesis that leucine and insulin stimulate translation initiation in human skeletal muscle by phosphorylating 70-kDa ribosomal protein S6 kinase (p70(S6k)), we infused healthy a...

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Bibliographic Details
Published inAmerican journal of physiology: endocrinology and metabolism Vol. 44; no. 3; pp. E466 - E471
Main Authors GREIWE, Jeffrey S, GUIM KWON, MCDANIEL, Michael L, SEMENKOVICH, Clay F
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.09.2001
Subjects
Amino acids
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Insulin
Muscular system
Proteins
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
Human
Pancreatic hormone
Enzyme
Kinase
Protein synthesis
Transferases
Aminoacid
Leucine
Striated muscle
Insulin
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Summary:Amino acids and insulin have anabolic effects in skeletal muscle, but the mechanisms are poorly understood. To test the hypothesis that leucine and insulin stimulate translation initiation in human skeletal muscle by phosphorylating 70-kDa ribosomal protein S6 kinase (p70(S6k)), we infused healthy adults with leucine along (n=6), insulin alone (n=6), or both leucine and insulin (n=6) for 2 h.
ISSN:0193-1849
1522-1555