Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation

Prolonged infusions of 17beta-estradiol reduce fetal pulmonary vascular resistance (PVR), but the effects of endogenous estrogens in the fetal pulmonary circulation are unknown. To test the hypothesis that endogenous estrogen promotes pulmonary vasodilation at birth, we studied the hemodynamic effec...

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 50; no. 3; pp. H1005 - H1014
Main Authors PARKER, Thomas A, AFSHAR, Sam, KINSELLA, John P, GROVER, Theresa R, GEBB, Sarah, GERACI, Mark, SHAUL, Philip W, CRYER, Chad M. T, ABMAN, Steven H
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.09.2001
Subjects
Air breathing
Biological and medical sciences
Blood
Embryology: invertebrates and vertebrates. Teratology
Estrogens
Fetuses
Fundamental and applied biological sciences. Psychology
Gases
Heart
Organogenesis. Physiological fonctions
Physiological fonctions
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Vertebrates: respiratory system
Prostaglandin-endoperoxide synthase
Intramolecular oxidoreductases
Lung
Estrogen
Prostaglandin-I synthase
Respiratory system
Vasodilation
Vasomotricity
Isomerases
Fetus
Antagonist
Ungulata
Regional blood flow
Enzyme
Perinatal
Gene expression
Ovarian hormone
Nitric-oxide synthase
Vertebrata
Mammalia
Term pregnancy
Newborn animal
Sheep
Artiodactyla
Hemodynamics
Oxidoreductases
Sex steroid hormone
Hormonal receptor
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Summary:Prolonged infusions of 17beta-estradiol reduce fetal pulmonary vascular resistance (PVR), but the effects of endogenous estrogens in the fetal pulmonary circulation are unknown. To test the hypothesis that endogenous estrogen promotes pulmonary vasodilation at birth, we studied the hemodynamic effects of prolonged estrogen-receptor blockade during late gestation and at birth in fetal lambs.
ISSN:0363-6135
1522-1539