Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation

Prolonged infusions of 17beta-estradiol reduce fetal pulmonary vascular resistance (PVR), but the effects of endogenous estrogens in the fetal pulmonary circulation are unknown. To test the hypothesis that endogenous estrogen promotes pulmonary vasodilation at birth, we studied the hemodynamic effec...

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 50; no. 3; pp. H1005 - H1014
Main Authors PARKER, Thomas A, AFSHAR, Sam, KINSELLA, John P, GROVER, Theresa R, GEBB, Sarah, GERACI, Mark, SHAUL, Philip W, CRYER, Chad M. T, ABMAN, Steven H
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.09.2001
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Summary:Prolonged infusions of 17beta-estradiol reduce fetal pulmonary vascular resistance (PVR), but the effects of endogenous estrogens in the fetal pulmonary circulation are unknown. To test the hypothesis that endogenous estrogen promotes pulmonary vasodilation at birth, we studied the hemodynamic effects of prolonged estrogen-receptor blockade during late gestation and at birth in fetal lambs.
ISSN:0363-6135
1522-1539