Differential control of intrarenal blood flow during reflex increases in sympathetic nerve activity

The role of renal sympathetic nerve activity (RSNA) in the physiological regulation of medullary blood flow (MBF) remains ill defined, yet regulation of MBF may be crucial to long-term arterial pressure regulation. To investigate the effects of reflex increases in RSNA on intrarenal blood flow distr...

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Bibliographic Details
Published inAmerican journal of physiology. Regulatory, integrative and comparative physiology Vol. 49; no. 1; pp. R62 - R68
Main Authors LEONARD, Bridget L, MALPAS, Simon C, DENTON, Kate M, MADDEN, Anna C, EVANS, Roger G
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 2001
Subjects
Biological and medical sciences
Circulatory system
Fundamental and applied biological sciences. Psychology
Kidneys
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Nervous system
Reflexes
Vertebrates: nervous system and sense organs
Sympathetic nerve
Regional blood flow
Nervous control
Vasoconstriction
Rabbit
Lagomorpha
Sympathetic nervous system
Kidney
Vasomotricity
Vertebrata
Mammalia
Urinary system
Hypoxia
Arterial pressure
Hemodynamics
Parasympathetic nervous system
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Summary:The role of renal sympathetic nerve activity (RSNA) in the physiological regulation of medullary blood flow (MBF) remains ill defined, yet regulation of MBF may be crucial to long-term arterial pressure regulation. To investigate the effects of reflex increases in RSNA on intrarenal blood flow distribution, we exposed pentobarbital sodium-anesthetized, artificially ventilated rabbits (n=7) to progressive hypoxia while recording RSNA, cortical blood flow (CBF), and MBF using laser-Doppler flowmetry.
ISSN:0363-6119
1522-1490