Comparative studies on the genotoxic activity of a new palladium (II) acidocomplex vs cisplatin in human blood lymphocytes in vitro

• Published in: Biomeditsinskaia khimiia Vol. 59; no. 1; p. 107
• Main Authors: Grekhova, A K, Gorbacheva, L B, Ivanova, N A, Efimenko, I A, Osipov, A N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.01.2013
• Subjects: Adult; Cisplatin - pharmacology; Cross-Linking Reagents - pharmacology; DNA - metabolism; DNA Damage; DNA-Binding Proteins - metabolism; Dose-Response Relationship, Drug; Female; Humans; Lymphocytes - metabolism; Lymphocytes - pathology; Palladium - pharmacology; Reactive Oxygen Species - metabolism

A comparative study on the genotoxic activity of cisplatin versus morfozol, the first representative of a new class of cation-anion complexes of palladium [AH]2[PdCl4] (where A-methylmorpholine) has been performed using human lymphocytes in vitro. The results of the DNA-DNA cross-linking activity in...