Comparative studies on the genotoxic activity of a new palladium (II) acidocomplex vs cisplatin in human blood lymphocytes in vitro

A comparative study on the genotoxic activity of cisplatin versus morfozol, the first representative of a new class of cation-anion complexes of palladium [AH]2[PdCl4] (where A-methylmorpholine) has been performed using human lymphocytes in vitro. The results of the DNA-DNA cross-linking activity in...

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Published inBiomeditsinskaia khimiia Vol. 59; no. 1; p. 107
Main Authors Grekhova, A K, Gorbacheva, L B, Ivanova, N A, Efimenko, I A, Osipov, A N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2013
Subjects
Adult
Cisplatin - pharmacology
Cross-Linking Reagents - pharmacology
DNA - metabolism
DNA Damage
DNA-Binding Proteins - metabolism
Dose-Response Relationship, Drug
Female
Humans
Lymphocytes - metabolism
Lymphocytes - pathology
Palladium - pharmacology
Reactive Oxygen Species - metabolism
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Summary:A comparative study on the genotoxic activity of cisplatin versus morfozol, the first representative of a new class of cation-anion complexes of palladium [AH]2[PdCl4] (where A-methylmorpholine) has been performed using human lymphocytes in vitro. The results of the DNA-DNA cross-linking activity investigations showed that both compounds studied exhibited biphasic dose-effect relationship: a linear decrease in the DNA percent in the comet tail and the region of the "plateau". However, in the "plateau" region, morfozol reduced the DNA percent in the comet tail up to 6 times while cisplatin caused a 2-fold decrease only. Morfozol, like cisplatin, inducing DNA-protein cross-linking and generating reactive oxygen species, was more effective than cisplatin.
ISSN:2310-6972