Risk factors of cytomegalovirus infection in patients with failed corneal grafts

• Published in: Chung-hua yen k'o tsa chih Vol. 60; no. 2; p. 137
• Main Authors: Zang, Y X, Peng, R M, Qu, Y, Liu, X Z, Hong, J
• Format: Journal Article
• Language: Chinese
• Published: China 11.02.2024
• ISSN: 0412-4081
• DOI: 10.3760/cma.j.cn112142-20231120-00242

To investigate the levels of cytomegalovirus (CMV) infection and associated risk factors in corneal transplant recipients who experienced transplant failure. This was a case-control study. Clinical data from 576 cases (576 eyes) of patients who underwent repeat corneal transplant surgery at the Department of Ophthalmology, Peking University Third Hospital, due to corneal transplant failure from January 2016 to May 2022 were collected. Of these, 305 were male and 271 were female, with a median age of 44.0 (0.7, 91.0) years. The CMV infection rate was analyzed based on the detection of CMV DNA in aqueous humor or corneal tissue during corneal transplant surgery. Patients were divided into the CMV group (CMV DNA positive) and the control group (herpes virus DNA negative). The main research indicators included the CMV infection rate, clinical characteristics, and risk factors in corneal transplant recipients. Chi-square tests and binary logistic analysis were used to compare differences between the two groups in