Diagnosis Significance of the Levels of Cytokines IL-6, IL-10 and CXCL-13 in Cerebrospinal Fluid for Central Nervous System Infiltration of Lymphoma

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 31; no. 1; p. 130
• Main Authors: Liu, Li-Xin, Liu, Jing-Hua, Wang, Ji-Gang, Tong, Dan-Jiang, Meng, Guang-Han, Li, Min-Yan, Zhou, Fan
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2023
• Subjects: Central Nervous System; Cytokines; Humans; Interleukin-10; Interleukin-6; Lymphoma; lymphoma central nervous system infiltration; CXCL-13; IL-10; IL-6
• ISSN: 1009-2137
• DOI: 10.19746/j.cnki.issn.1009-2137.2023.01.021

To evaluate the diagnostic value of the expression levels of cytokines interleukin-6(IL-6), interleukin-10 (IL-10) and chemokine （C-X-C motif） ligand-13 (CXCL-13) in cerebrospinal fluid (CSF) for central nervous system infiltration of lymphoma. Forty patients diagnosed as lymphoma or acute lymphoblastic leukemia in General Hospital of Northern Theater Command from July 2020 to July 2021 were collected and recorded their CSF indexes, including pressure, protein, Pandy test, nucleated cell count, glucose and chlorine content in CSF. The levels of cytokines IL-6, IL-10 and CXCL-13 were detected by Enzyme-linked immunosorbent assay. The patients were divided into CNSI (central nervous system infiltration) group and non-CNSI group, the average levels of IL-6, IL-10, CXCL-13 and IL-10/IL-6 ratio in CNSI group were higher than those in non-CNS group, but the difference of IL-10/IL-6 ratio between the two groups was statistically significant ( <0.05). Then the patients were divided into protein elevated( =14) group a