Investigation of the Effects of Curcumin and Gallic Acid in the Liver and Kidneys of Rat Ovarian Transplant Recipients

• Published in: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation Vol. 22; no. 9; p. 706
• Main Authors: Keles, Papatya, Sapmaz, Tansel, Basol Baki, Kubra, Topkaraoglu, Sude, Erdem, Esra, Sevgin, Kubra, Kuras, Sibel, Pence, Mahmud Esad, Aktas, Selman, Karip, Burak
• Format: Journal Article
• Language: English
• Published: Turkey 01.09.2024
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Antioxidants - pharmacology; Apoptosis - drug effects; bcl-2-Associated X Protein - metabolism; Curcumin - pharmacology; Drug Therapy, Combination; Female; Gallic Acid - pharmacology; Inflammation Mediators - metabolism; Interleukin-6 - metabolism; Kidney - drug effects; Kidney - pathology; Liver - drug effects; Liver - metabolism; Liver - pathology; Ovary - drug effects; Ovary - metabolism; Ovary - pathology; Ovary - transplantation; Oxidative Stress - drug effects; Proto-Oncogene Proteins c-bcl-2 - metabolism; Rats, Sprague-Dawley
• ISSN: 2146-8427; 2146-8427
• DOI: 10.6002/ect.2023.0327

Recent studies have shown that oxidative stress, inflammation, and apoptosis play substantial roles in the pathogenesis of tissue damage and distant organ damage during ovarian transplantation. Because of their potential antioxidant and anti-inflammatory properties, investigating natural compounds like curcumin and gallic acid is crucial. This study investigated the effects of curcumin, gallic acid, and their combination on liver and kidney tissues in a rat model of ovarian transplantation. For this study, we used 42 adult female Sprague-Dawley rats aged 11 to 12 weeks, which we randomly divided into 6 groups. After the transplant procedures, we performed histopathological analysis, biochemical examinations, and statistical analysis. Significant damage was shown in the liver and kidney tissues of the ovarian transplant only and transplant plus corn oil groups compared with the control group, as evidenced by histopathological evaluation, increased BAX/BCL-2 intensity indicating apoptotic activity, and elevated interleukin 6 levels. However, treatment with curcumin, gallic acid, or their combination attenuated these adverse effects, suggesting potential protective effects against transplant-induced injury. Our findings highlight the therapeutic potential of these compounds in mitigating tissue damage and inflammation associated with ovarian transplant.