Application of PRAME immunohistochemistry in the differential diagnosis of primary endometrial and endocervical adenocarcinomas

• Published in: Zhonghua bing li xue za zhi Vol. 53; no. 6; p. 552
• Main Authors: Wei, X, Zheng, Z, Shi, Q Y, Wang, C S, Meng, F Q, Chen, L
• Format: Journal Article
• Language: Chinese
• Published: China 08.06.2024
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adult; Aged; Aged, 80 and over; Antigens, Neoplasm - metabolism; Biomarkers, Tumor - metabolism; Diagnosis, Differential; Endometrial Neoplasms - diagnosis; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; Female; Humans; Immunohistochemistry; Middle Aged; Sensitivity and Specificity; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology
• ISSN: 0529-5807
• DOI: 10.3760/cma.j.cn112151-20230908-00156

To investigate the diagnostic value of preferentially expressed antigen in melanoma (PRAME) immunohistochemical staining in differential diagnosis of primary endometrial and endocervical adenocarcinomas. Eighty-seven cases of endometrial adenocarcinoma and sixty-three cases of cervical adenocarcinoma were collected from May 2018 to November 2023 in the Department of Pathology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School and all the cases were subject to PRAME immunohistochemical staining. The difference of PRAME expression between endometrial and endocervical adenocarcinomas was analyzed. In 87 cases of endometrial adenocarcinoma, patients' age ranged from 35 to 71 years (average 59 years, median 59 years); in 63 cases of cervical adenocarcinoma patients' age ranged from 28 to 80 years (average 49 years, median 47 years). Seventy-eight cases (78/87, 89.7%) of endometrial adenocarcinoma; 2 cases (2/63, 3.2%) of cervical adenocarcinoma showed positive PRAME staining