Effects of central infusion of ANG II and losartan on the cardiac baroreflex in rabbits

The effect of chronic activation or inhibition of central ANG II receptors on cardiac baroreflex function in conscious normotensive rabbits was examined. Animals received a fourth ventricular (4V) infusion of ANG II (30 and 100 ng/h), losartan (3 and 30 mug/h), or Ringer solution (2 mul/h) for 2 wk.

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 47; no. 2; pp. H558 - H566
Main Authors GAUDET, E, GODWIN, S. J, HEAD, G. A
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.02.2000
Subjects
Antihypertensive agents
Biological and medical sciences
Blood pressure
Brain
Cardiovascular system
Drug therapy
Medical sciences
Pharmacology. Drug treatments
Rabbits
Side effects
Heart
Rabbit
Injection
Lagomorpha
Route of administration
Long term
Heart rate
Renin angiotensin system
Vertebrata
Mammalia
Animal
Baroreflex
Losartan
Blood pressure
Circulatory system
Hemodynamics
Angiotensin II
Fourth cerebral ventricle
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Summary:The effect of chronic activation or inhibition of central ANG II receptors on cardiac baroreflex function in conscious normotensive rabbits was examined. Animals received a fourth ventricular (4V) infusion of ANG II (30 and 100 ng/h), losartan (3 and 30 mug/h), or Ringer solution (2 mul/h) for 2 wk.
ISSN:0363-6135
1522-1539