Sudden renal function deterioration in an elderly patient on vancomycin therapy for endocarditis

Vancomycin is currently the drug of choice in meticillin-resistant Staphylococcus aureus (MRSA) infection. It is also used prophylactically in some situations in which the patient is at risk for endocarditis. It is often used in combination with other antibacterials in the treatment of endocarditis...

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Bibliographic Details
Published inČasopis lékařů českých Vol. 151; no. 11; p. 531
Main Authors Tesfaye, Hundie, Lukášková, Jiřina, Hořínková, Jana
Format Journal Article
LanguageEnglish
Published Czech Republic 2012
Subjects
Aged
Anti-Bacterial Agents - adverse effects
Endocarditis - drug therapy
Female
Glomerular Filtration Rate - drug effects
Humans
Kidney - drug effects
Kidney - physiopathology
Vancomycin - adverse effects
Vancomycin - therapeutic use
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Summary:Vancomycin is currently the drug of choice in meticillin-resistant Staphylococcus aureus (MRSA) infection. It is also used prophylactically in some situations in which the patient is at risk for endocarditis. It is often used in combination with other antibacterials in the treatment of endocarditis and is a potential nephrotoxin. Various consensus guidelines differ in their interpretation of vancomycin plasma concentrations. This paper describes a case of a 72-years old Caucasian female patient, who developed significant renal impairment when prescribed vancomycin in combination with penicillin for the treatment of endocarditis, caused by Streptococcus pneumoniae.
ISSN:0008-7335