Association of ulcerative colitis with fork head/winged helix transcription factor-3 gene polymorphisms in Chinese patients

• Published in: Chung-hua nei kʿo tsa chih Vol. 56; no. 3; p. 188
• Main Authors: Zhang, D G, Xia, X P, Wu, H, Lin, X Q, Jiang, L J, Ding, R, Jiang, Y
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2017
• Subjects: Adult; Alleles; Asian Continental Ancestry Group - genetics; China; Colitis, Ulcerative - ethnology; Colitis, Ulcerative - genetics; Female; Gene Frequency; Genotype; Haplotypes; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Transcription Factor 3 - genetics; Winged-Helix Transcription Factors - genetics; Fork head/winged helix transcription factor-3; Polymorphism, single nucleotide; Colitis, ulcerative
• ISSN: 0578-1426
• DOI: 10.3760/cma.j.issn.0578-1426.2017.03.008

To investigate the association of ulcerative colitis (UC) with fork head/winged helix transcription factor-3 ( 3) polymorphisms in Han population in Zhejiang province, China. A total of 381 UC patients and 490 healthy controls were enrolled in this study.The four single nucleotide polymorphisms (SNPs) of 3 (rs3761547, rs2232365, rs2294021, rs3761548) were examined by SNaPshot.The analyses of linkage disequilibrium (LD) and haplotype were also performed in all study subjects. When male and female UC patients were compared with their corresponding controls respectively, the alleles and genotypes of the four SNPs were not statistically different (all >0.05). According to severity and location of the disease, the UC patients were divided into different subgroups. The alleles (C, G, A) of (rs2232365, rs2294021, rs3761548) were more frequent in male patients with severe UC than in the male controls (69.6% vs 34.3%, =0.001; 69.6% vs 34.3%, =0.001; 39.1% vs 14.4%, =0.002, respectively). As compared with the female co